Rano Burkhanovna Alieva

Ministry of Health,
Republic of Uzbekistan

Abstract Title: Correlation of Echocg Parameters in Pts With Breast Cancer with the Number of Chemotherapy Courses

Biography:

Alieva R.B. has completed his PhD at the 2019 at the PSSPMCC and postdoctoral studies fromRSSPMCC at 2024. He is the director of Lipid Center of Uzbekistan Cardiology Assosuation. He has published more than 85 papers in reputed journals and has been serving as an editorial board member of repute.

Research Interest:

Republican Specialized Scientific Practical Medical Center Of Cardiology, Tashkent, Uzbekistan 55 patients with breast cancer were examined after surgical treatment. All patients received both neoadjuvant and adjuvant chemotherapy. Depending on the number of chemotherapy courses, three groups were identified: group I – 18 patients with chemotherapy courses from 2 to 4 (median 2.8±1.1); GroupII – 26 patients with chemotherapy courses from 5 to 9 (median 7.5±1.2); Group III – 11 patients with chemotherapy courses from 10 to 20 (median 13.9±3.2). When conducting an echocardiography study, the following indicators were taken into account: stroke volume (SV, ml), left ventricular ejection fraction (LVEF, %), myocardial mass (LVMM, g), and its indexed indicator (LVMI), relative wall thickness (RW).

Results: Analysis of intracardiac hemodynamic parameters in the analyzed groups established that patients in group III were characterized by the lowest values of CO (by 13.2 and 8.0 ml compared with similar indicators in groups I and II) and LVEF (by 13.3 and 5.8% compared with groups I and II), as well as LVMM (difference with I group – 15.9 g and with II group – 2.6 g) and its indexed indicator (difference 28.9 and 2.6 g/m2, respectively with the I and II groups). The calculation of the RWT established that the lowest values of the were also observed in women of the III group, which amounted to 0.39±0.05 units, i.e. was <0.45 units. This was due to the small number of people with RWTh a level ≥ 0.45 units, which occurred in only 18.2% of women in this group. Assessment of LV iMM and RWT in order to clarify the geometric type of LV showed that the majority of women had LV iMM>N, RWT <0.45 - which corresponds to eccentric LV hypertrophy, and only 16 patients (29.1% of the entire sample) had LV iMM>N , RWT ≥0.45 – which corresponds to concentric LV hypertrophy.All women had previously received chemotherapy. The average number of chemotherapy courses in the group as a whole was 7.3±4.3 courses. When conducting a correlation analysis between the number of chemotherapy courses and LVEF values, an inverse relationship was established (p<0.05), i.e. The more courses of chemotherapy the patients received, the worse the LVEF values were (p=0.037; t= -2.142; r= -0.287).

Conclusions: In breast cancer, as the number of chemotherapy courses taken increased, there was a decrease in SV and LVEF, while the majority of women were characterized by the development of eccentric LV hypertrophy. However, it is also necessary to take into account the side effects of chemotherapy itself, especially its cardiotoxicity.