Yalan Deng

Shanghai Jiao Tong University, School of Medicine, Shanghai,
China

Abstract Title: The Impact of the Micra AV Leadless Pacemaker on Cardiac Function: a Real-World Study

Biography:

Dr. Deng studied Clinical Medicine at the Shanghai Jiaotong University and graduated as MD in 2022. She then joined the research group of Prof. Wu at the Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. She is currently pursuing her PhD.

Research Interest:

The study enrolled 76 patients implanted with Micra AV leadless pacemaker. After implantation, patients with high-grade atrioventricular (AV) block experienced a significant reduction in left ventricular ejection fraction (LVEF) (67.0±5.07% vs 63.4±4.42%, P<0.001) and stroke volume (79.7 ± 21.4ml vs 71.0 ± 16.3ml, 0.007), with 9 patients showing a decrease in LVEF of more than 10%. However, cardiac output per minute significantly increased (5.2L/min vs 4.2L/min, P<0.041), and the left ventricular end-diastolic diameter was significantly reduced compared to preoperative measurements (49.9±5.38mm vs 48.6±4.96mm). Preoperative LVEF（OR=1.56, 95%CI 1.12~2.17, P=0.001） and stroke volume levels（OR=1.15, 95%CI 1.04~1.28, P=0.001） were important predictors of postoperative LVEF reduction. In patients with sick sinus syndrome, there was no significant difference in LVEF before and after implantation. Furthermore, no patients developed pacemaker syndrome. In this study, the overall atrioventricular synchrony (AVS) was 81.2%, with 82.4% in the AV block group and a lower rate of 70.6% in the sick sinus syndrome group. In clinical practice, a comprehensive analysis of various factors should be conducted to evaluate changes in LVEF. Patients at high risk of AV block may derive greater benefit from the Micra AV leadless pacemaker.