Evgeny Pokushalov

Triangel Scientific,
United States of America

Abstract Title: Efficacy of AI-Guided Dietary Supplement Prescriptions Versus Traditional Methods for Lowering LDL Cholesterol: A Randomized Parallel-Group Pilot Study

Biography:

MD (Б-1 077979; University of Russia, 2002), PhD, Professor of Medicine. Present Appointment: since 2020 Deputy Director of the Center for New Medical Technologies 1997-1999 Residency of Cardiology, Research Institute of Cardiology, Tomsk 1999-2002 Post-graduate course of Cardiosurgery, Research Institute of Cardiology, Tomsk 2003 Hopital Haut-Leveque, Bordeaux-Pessac, France 2004 St Georg Hospital, Hamburg, Germany 2005 San Raffaele University Hospital, Milan, Italy 2012 Principles and Practice of Clinical Research, Harvard Medical School, USA

Research Interest:

Emerging evidence suggests that personalized dietary supplement regimens can significantly influence lipid metabolism and cardiovascular risk. The efficacy of AI-guided dietary supplement prescriptions, compared to standard physician-guided prescriptions, remains underexplored. In a randomized, parallel-group pilot study, 70 patients aged 40-75 years with LDL-C levels between 70-190 mg/dL were enrolled. Participants were randomized to receive either AI-guided dietary supplement prescriptions or standard physician-guided prescriptions for 90 days. The primary endpoint was the percent change in LDL-C levels. Secondary endpoints included changes in total cholesterol, HDL-C, triglycerides, and hsCRP. Supplement adherence and side effects were monitored. Sixty-seven participants completed the study. The AI-guided group experienced a 25.3% reduction in LDL-C levels (95% CI: -28.7% to -21.9%), significantly greater than the 15.2% reduction in the physician-guided group (95% CI: -18.5% to -11.9%; p<0.01). Total cholesterol decreased by 15.4% (95% CI: -19.1% to -11.7%) in the AI-guided group compared to 8.1% (95% CI: -11.5% to -4.7%) in the physician-guided group (p<0.05). Triglycerides were reduced by 22.1% (95% CI: -27.2% to -17.0%) in the AI-guided group versus 12.3% (95% CI: -16.7% to -7.9%) in the physician-guided group (p<0.01). HDL-C and hsCRP changes were not significantly different between groups. The AI-guided group received a broader variety of supplements, including plant sterols, omega-3 fatty acids, red yeast rice, coenzyme Q10, niacin, and fiber supplements. Side effects were minimal and comparable between groups. AI-guided dietary supplement prescriptions significantly reduce LDL-C and triglycerides more effectively than standard physician-guided prescriptions, highlighting the potential for AI-driven personalization in managing hypercholesterolemia.