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Zongliang Yu

 

Zongliang Yu

Beijing University of Chinese Medicine, China

Abstract Title: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a predictor of cardiovascular and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES III

Biography:

Zongliang Yu possesses professional expertise in the medical field and is dedicated to advancing healthcare development. His primary research focuses include: mechanisms of programmed cell death and clearance in atherosclerosis and cardiovascular metabolic diseases; inflammation, oxidative stress, and lipid metabolism; and the cardiovascular protective effects of natural medicines.

Research Interest:

INTRODUCTION: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel composite indicator for assessing the risk of several diseases.

METHODS: This study included 3753 adult MASLD patients from NHANES III. Weighted multivariate Cox proportional risk models and restricted cubic spline (RCS) were used to assess the association between NHHR and all-cause and cardiovascular mortality. Segmented Cox proportional risk models were used to determine hazard ratios at and on either side of the inflection point.

RESULTS: A total of 1633 all-cause deaths were recorded during follow-up of 3753 patients, of which 455 were due to cardiovascular disease. Analysis of the Cox proportional hazards model, which used an RCS fit, showed a significant U-shaped relationship between the NHHR index and all-cause mortality, with an inflection point of 3.54. Below the inflection point, each unit increase in the NHHR index was associated with a 2% reduction in the risk of all-cause mortality. Above the inflection point, the risk of all-cause mortality increased by 6% for each unit increase in the NHHR index. There was also a linear relationship between the NHHR index and cardiovascular mortality, with a 14% increase in risk of cardiovascular death for each unit increase in the NHHR index.

CONCLUSION: The NHHR index showed a significant U-shaped relationship with all-cause mortality and a linear relationship with cardiovascular mortality. Routine monitoring of NHHR may be useful in assessing the risk of death in patients with MASLD.